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HH1 AhN[8W CCv ǜaaXXC), TA?C>$<>|ry88TT\||8 83?`x}yem?F߿{5LeAl@F7o!d2yQ?-lyoɾu$ݺqI=oՓ!?Fw5c.<9ߏb=<3Ufa JdqP͹flָ=nfc]q^P@X'zڦzl[ۻ$m @W6cU=ޭnԏnѓUgنL6 ꓞl-%\OkEQ?ZNm96 :v2v;&oԏdtL竷!zC=WdqM/q=*J燬kj@ K+^m+k˕Gh*38idl_ITR蒸uղHi+Ξ@r9șF7,R{M %Lidck9ȨEs&Fjii=H"iU)mHH}OZ endstream endobj 239 0 obj <>stream hތ;0 yHU%R0!?*1%/~(PUU#߉<T> endobj 241 0 obj <> endobj 242 0 obj <>stream application/pdf Molecular Typing of Imported Dengue Virus(DENV) Isolates from Patients in the Far East ofRussia Background: Dengue remains the most rapidly spreading mosquito-borne viral infection in the world with 30-fold growth during the last 50 years and its expansion to new areas. Dengue virus transmissions are effected by urbanization and international travel. Detection, identification and quantitation of Dengue virus beyond its endemic regions during global warming are necessary to estimate an epidemiological risk. Methods: Dengue virus strains were isolated from blood samples of patients with unknown fever. To confirm clinical diagnosis both RTPCR and ELISA to detect IgM/IgG were used. Sequencing of RT-PCR products corresponding to C-prM, E and NS5 genes with subsequent phylogenetic analysis performed for molecular typing. Results: During 2012-14 Dengue fever imported cases were confirmed in blood samples of 13 from 95 patients with unknown fever (13,7%) in Khabarovsk, Primorye and Sakhalin regions of the Far East, Russia. Using permissive tissue culture Vero E6 and susceptible suckling mice five Dengue strains of 1 and 3 types have been isolated. RT-PCR with Dengue serotype-specific primers and phylogenetic analysis of nucleotide sequences of RT-PCR products corresponding to C-prM, E and NS5 genes revealed Dengue viruses 1, 2 and 3 types. Conclusions: For the first time in Russia Dengue fever imported cases were confirmed by means of RT-PCR, ELISA and virus isolation. Molecular typing revealed Dengue viruses 1, 2 and 3 types in blood sample of patients after their return from travel to subtropical endemic regions. © 2015 Pukhovskaya NM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Pukhovskaya NM* Morozova OV Bakhmetyeva SV Zdanovskaya NI Belozerova NB Pochinkova NA and Ivanov LI Molecular typing Dengue virus RT-PCR 2016-06-30T14:15:03+05:30 2016-06-30T14:15:04+05:30 2016-06-30T14:15:04+05:30 Adobe InDesign CS6 (Windows) uuid:68301ba7-d3d7-4837-9a9f-79769bd8b0ee xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:051A0285853EE61199449B81D5FAE482 proof:pdf xmp.iid:041A0285853EE61199449B81D5FAE482 xmp.did:596E10D992C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-06-30T14:15:03+05:30 Citation: Pukhovskaya NM, Morozova OV,Bakhmetyeva SV, Zdanovskaya NI, Belozerova NB,et al. (2015) Molecular Typing of Imported DengueVirus (DENV) Isolates from Patients in the Far Eastof Russia. J Virol Emerg Dis 1 (1): doi: http://dx.doi.org/10.16966/jved.101 Corresponding author: Natalia M. Pukhovskaya, Khabarovsk Atiplague Station Rospotrebnadzor,7 Sanitarny Bystreet, 680037, Khabarovsk, Russia; Tel: +7 4212334597; Fax: +74212334526;E-mail: pukhovskaya@mail.ru Adobe PDF Library 10.0.1 False endstream endobj 243 0 obj <> endobj xref 0 2457 0000000000 65535 f 0000252487 00000 n 0000252951 00000 n 0000252996 00000 n 0000263172 00000 n 0000263231 00000 n 0000263789 00000 n 0000263819 00000 n 0000263954 00000 n 0000280984 00000 n 0000281760 00000 n 0000282051 00000 n 0000311706 00000 n 0000311962 00000 n 0000331192 00000 n 0000331459 00000 n 0000348861 00000 n 0000349115 00000 n 0000366568 00000 n 0000366855 00000 n 0000383458 00000 n 0000383723 00000 n 0000417355 00000 n 0000417392 00000 n 0000417468 00000 n 0000417748 00000 n 0000417833 00000 n 0000417893 00000 n 0000418390 00000 n 0000418415 00000 n 0000418551 00000 n 0000432490 00000 n 0000432575 00000 n 0000432635 00000 n 0000433139 00000 n 0000433452 00000 n 0000433588 00000 n 0000438360 00000 n 0000460757 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 242 0 obj <>stream application/pdf Molecular Typing of Imported Dengue Virus(DENV) Isolates from Patients in the Far East ofRussia Background: Dengue remains the most rapidly spreading mosquito-borne viral infection in the world with 30-fold growth during the last 50 years and its expansion to new areas. Dengue virus transmissions are effected by urbanization and international travel. Detection, identification and quantitation of Dengue virus beyond its endemic regions during global warming are necessary to estimate an epidemiological risk. Methods: Dengue virus strains were isolated from blood samples of patients with unknown fever. To confirm clinical diagnosis both RTPCR and ELISA to detect IgM/IgG were used. Sequencing of RT-PCR products corresponding to C-prM, E and NS5 genes with subsequent phylogenetic analysis performed for molecular typing. Results: During 2012-14 Dengue fever imported cases were confirmed in blood samples of 13 from 95 patients with unknown fever (13,7%) in Khabarovsk, Primorye and Sakhalin regions of the Far East, Russia. Using permissive tissue culture Vero E6 and susceptible suckling mice five Dengue strains of 1 and 3 types have been isolated. RT-PCR with Dengue serotype-specific primers and phylogenetic analysis of nucleotide sequences of RT-PCR products corresponding to C-prM, E and NS5 genes revealed Dengue viruses 1, 2 and 3 types. Conclusions: For the first time in Russia Dengue fever imported cases were confirmed by means of RT-PCR, ELISA and virus isolation. Molecular typing revealed Dengue viruses 1, 2 and 3 types in blood sample of patients after their return from travel to subtropical endemic regions. © 2015 Pukhovskaya NM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Pukhovskaya NM* Morozova OV Bakhmetyeva SV Zdanovskaya NI Belozerova NB Pochinkova NA and Ivanov LI Molecular typing Dengue virus RT-PCR 2016-06-30T14:15:03+05:30 2016-06-30T14:15:23+05:30 2016-06-30T14:15:23+05:30 Adobe InDesign CS6 (Windows) uuid:2384adf4-f8c4-4813-9c24-24ef65e53181 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:051A0285853EE61199449B81D5FAE482 proof:pdf xmp.iid:041A0285853EE61199449B81D5FAE482 xmp.did:596E10D992C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-06-30T14:15:03+05:30 Citation: Pukhovskaya NM, Morozova OV,Bakhmetyeva SV, Zdanovskaya NI, Belozerova NB,et al. (2015) Molecular Typing of Imported DengueVirus (DENV) Isolates from Patients in the Far Eastof Russia. J Virol Emerg Dis 1 (1): doi: http://dx.doi.org/10.16966/jved.101 Corresponding author: Natalia M. Pukhovskaya, Khabarovsk Atiplague Station Rospotrebnadzor,7 Sanitarny Bystreet, 680037, Khabarovsk, Russia; Tel: +7 4212334597; Fax: +74212334526;E-mail: pukhovskaya@mail.ru Adobe PDF Library 10.0.1 False endstream endobj 243 0 obj <> endobj 2458 0 obj <>/Metadata 242 0 R/Names 2459 0 R/Outlines 174 0 R/PageMode/UseOutlines/Pages 241 0 R/StructTreeRoot 244 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 242 2 0000692898 00000 n 0000701142 00000 n 2458 1 0000703026 00000 n trailer <<56EDACACE730954DBFE54D76F6FDA08B>]/Prev 116>> startxref 703230 %%EOF